Association studies examine well-characterized sites of the genome - the genetic markers - to identify potential associations between the former and a phenotype (disease status, blood pressure, response to medicine in the biomedical domain ... ; wheat flour plasticity, muscular mass in the agronomic domain ...).
Societal and economic impacts are expected from advances in this active research field, at the cross of genetics and bioinformatics: scientific progress in medicine (evidence of individual genetic susceptibility to drugs, personalized medicine), societal evolution (early gene susceptibility detection for better prevention or surveillance, population aging), control of public health expenditure, nutrition improvement for entire populations.
In the biomedical domain, the focus of this meeting day will be set on methods integrating evolutionary information in association studies. Recent advances will be discussed at the genome scale and strategies for genome-wide association studies (GWASs) will be described. Besides, as plant genetics nowadays opens to genome-wide investigations, some presentations will address this peculiar topic.
The purpose of this scientific meeeting day consists in bringing together researchers in biology, genetics, biostatistics and bioinformatics which are interested in the design, implementation and validation of association studies and more pecularly GWAS strategies.
The aim is to share knowledge and stimulate further research. During the scientific meeting day, five invited speakers will present works relative to recent advances in the domain considered.
9H30-10H30 Kinship, heritability and genetic effect sizes
David Balding, Institute of Genetics,University College London, England
10H30-11H00 pause café
11H00-12H00 Genome-wide association mapping to candidate polymorphism
resolution in the unsequenced barley genome
Jordi Comadran,The James Hutton Institute, Invergowrie, Dundee, Scotland
12H00-14H00 buffet déjeunatoire offert (limité à 50 personnes)
14H00-15H00 On the use of evolutionary information in haplotype
association tests - coalescent-based and phylogeny-based tests
Claire Bardel, UMR CNRS 5558, Laboratoire de biométrie et biologie
évolutive, équipe biostatistiques - santé, Lyon
15H00-16H00 Segregation / linkage / association: a graphical model point
of view - IBS- IBD-based approaches
Gregory Nuel, MAP5 - UMR CNRS 8145, Université Paris Descartes, Paris
16H00-16H30 pause café
16H30-17H30 Genome Wide Association Studies in plants: strategy
implemented in Arabidopsis thaliana
Vincent Segura, invited researcher at the Nordborg Group - Population
GMI, Gregor Mendel Institute for Molecular Plant Biology, Vienna, Austria
The RAGAS scientific meeting will be held at the
Institut de Recherche Thérapeutique (IRT UN, 8 quai Moncousu, Nantes;